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Photolinker ii4/10/2023 ![]() ![]() This process starts a long time before there is a manifest disorder of glucose metabolism. The progressive destruction of the pancreatic β cells by cytotoxic lymphocytes is typical for the disease course in IDDM. Under particular circumstances, in particular in the postnatal phase, antigens taken up through the food such as bovine serum albumin can induce an immune response which can trigger an autoaggressive process due to homologies to endogenous structures. Viral antigens have been discussed among others in this connection which have partial homologies to endogenous structures. The environmental factors involved in the development of IDDM are probably exogenic peptide sequences that act as an immunogen. Thus it is possible to define a risk group for IDDM by an analysis of these alleles (cf. For example in the case of IDDM, at the genetic risk factor level, only a few alleles of the MHC class II antigens are closely associated with this disease. It is now certain that, in addition to a genetic disposition, environmental factors also play a role in the development of these diseases. The elucidation of the molecular interrelations in the development of autoimmune diseases such as rheumatoid arthritis and juvenile diabetes (IDDM) has rapidly advanced in recent years and has meanwhile revealed concrete applications for early diagnosis and for a causal therapy of these diseases. 18, 1995 (abandoned).The present invention concerns peptides which cause an autoimmune reaction, complexes of these peptides with molecules of the major histocompatability complex (MHC), T cell subpopulations which react with the peptides or/and the complexes of peptides and MHC molecules as well as diagnostic and therapeutic uses of these compounds. 5, 1997 (abandoned), which is a continuation of application Ser. 30, 1999 now abandoned, which is a continuation of application Ser. This application is a divisional of application Ser.
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